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North Brunswick, NJ 08902
URG101 is combination of lidocaine and heparin instilled directly into the bladder via catheter. Lidocaine provides immediate symptom relief, while high dose heparin (also a GAG) helps to mechanically repair the damaged bladder lining.
The individual components of this combination therapy, Lidocaine HCl and heparin sodium, are FDA-approved products for use as a local anesthetic and an anticoagulant, respectively. It was demonstrated that when these components were mixed together and buffered by the addition of sodium bicarbonate, the resultant solution reduced symptoms of pelvic pain and urgency upon instillation into a subject’s bladder. Most subjects exhibit both an acute benefit as well as sustained benefit from single and multiple treatments. This multimodal therapy achieves acute benefit for subjects who have no standard acute treatment for pelvic pain and urgency of bladder origin.
Our Phase II data shows the greatest separation from placebo ever published in IC/BPS
Source: Parsons et at. J Sex Med 2012;9:207–212